NSC 136916
4-Chloroquinoline-3-carboxylic acid ethyl ester
CAS: 13720-94-0
Molecular Formula: C12H10ClNO2
NSC 136916 - Names and Identifiers
| Name | 4-Chloroquinoline-3-carboxylic acid ethyl ester |
| Synonyms | NSC 136916 NSC 109461 AURORA 18125 4-CHLORO-3-QUINOLINECARBOXYLATE ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE ethyl 4-chloroquinoline-3-carboxylate 4-Chloroquinoline-3-carboxylic acid ethyl ester 4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester |
| CAS | 13720-94-0 |
| InChI | InChI=1/C12H10ClNO2/c1-2-16-12(15)9-7-14-10-6-4-3-5-8(10)11(9)13/h3-7H,2H2,1H3 |
| InChIKey | DWXQUAHMZWZXHP-UHFFFAOYSA-N |
NSC 136916 - Physico-chemical Properties
| Molecular Formula | C12H10ClNO2 |
| Molar Mass | 235.67 |
| Density | 1.286 |
| Melting Point | 46-48°C |
| Boling Point | 128-129 °C(Press: 0.2 Torr) |
| Flash Point | 152.5°C |
| Vapor Presure | 0.000189mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| pKa | 1.78±0.24(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.609 |
| MDL | MFCD00173407 |
NSC 136916 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
NSC 136916 - Introduction
4-Chloroquinoline-3-methylethyl ester, also known as 4-Chloroquinoline-3-methyl acetate, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Chloroquinoline -3-methyl ethyl ester is a colorless to pale yellow oily liquid.
-Melting point: Its melting point range is -80°C to -60°C.
-Boiling point: Its boiling point is about 180°C to 190°C.
-Solubility: Soluble in organic solvents such as chloroform and ethanol, almost insoluble in water.
Use:
-4-chloroquinoline -3-methyl ethyl ester is often used as an intermediate in organic synthesis. It can be further reacted for the synthesis of other compounds.
-It is also an important intermediate in the pharmaceutical field, used to synthesize the antimalarial drugs quinoline and o-chloroquine.
Preparation Method:
-4-chloroquinoline -3-methyl ethyl ester can be prepared by a variety of methods. A common preparation method is to react 3-methylquinoline with chloroacetic acid or ethyl chloroacetate, introduce chlorine atoms through substitution reaction, and esterify the methyl group and acetyl group on the quinoline ring.
Safety Information:
-4-chloroquinoline -3-methyl ethyl ester need to pay attention to safety when using. It may be irritating to the eyes, skin and respiratory system. Avoid contact with skin, eyes and use. At the same time, operate in a well-ventilated area and be equipped with appropriate protective equipment, such as gloves, goggles and protective masks.
-When storing, it should be stored in a cool, dry place, away from fire and flammable materials.
-When disposing of waste, follow local regulations and properly dispose of remaining 4-chloroquinoline-3-methylethyl ester.
Nature:
-Appearance: 4-Chloroquinoline -3-methyl ethyl ester is a colorless to pale yellow oily liquid.
-Melting point: Its melting point range is -80°C to -60°C.
-Boiling point: Its boiling point is about 180°C to 190°C.
-Solubility: Soluble in organic solvents such as chloroform and ethanol, almost insoluble in water.
Use:
-4-chloroquinoline -3-methyl ethyl ester is often used as an intermediate in organic synthesis. It can be further reacted for the synthesis of other compounds.
-It is also an important intermediate in the pharmaceutical field, used to synthesize the antimalarial drugs quinoline and o-chloroquine.
Preparation Method:
-4-chloroquinoline -3-methyl ethyl ester can be prepared by a variety of methods. A common preparation method is to react 3-methylquinoline with chloroacetic acid or ethyl chloroacetate, introduce chlorine atoms through substitution reaction, and esterify the methyl group and acetyl group on the quinoline ring.
Safety Information:
-4-chloroquinoline -3-methyl ethyl ester need to pay attention to safety when using. It may be irritating to the eyes, skin and respiratory system. Avoid contact with skin, eyes and use. At the same time, operate in a well-ventilated area and be equipped with appropriate protective equipment, such as gloves, goggles and protective masks.
-When storing, it should be stored in a cool, dry place, away from fire and flammable materials.
-When disposing of waste, follow local regulations and properly dispose of remaining 4-chloroquinoline-3-methylethyl ester.
Last Update：2024-04-09 21:11:58
Supplier List
Spot supply
Product Name: Ethyl4-chloroquinoline-3-carboxylate Request for quotationCAS: 13720-94-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Ethyl 4-Chloroquinoline-3-Carboxylate Visit Supplier Webpage Request for quotation
CAS: 13720-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 13720-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Ethyl4-chloroquinoline-3-carboxylate Request for quotationCAS: 13720-94-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Ethyl 4-Chloroquinoline-3-carboxylate Visit Supplier Webpage Request for quotationCAS: 13720-94-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Ethyl 4-Chloroquinoline-3-Carboxylate Visit Supplier Webpage Request for quotation
CAS: 13720-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 13720-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History